Dihexa, also known as N-hexanoic-Tyr-Ile-(6) aminohexanoic amide, is an oligopeptide drug derived from angiotensin IV that binds with high affinity to hepatocyte growth factor (HGF) and potentiates its activity at its receptor, c-Met. Dihexa has been found to potently improve cognitive function in animal models of Alzheimer’s disease-like mental impairment. In an assay of neurotrophic activity, Dihexa was found to be seven orders of magnitude more potent than brain-derived neurotrophic factor. An orally active, blood– brain barrier permeable compound was subsequently developed with the potential to treat Alzheimer’s disease and other disorders that would benefit from augmented synaptic connectivity.
- Dihexa Capsule 2mg, 5mg, 10mg, and 25mg #30 capsules
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