Pitolisant is a selective histamine 3 receptor antagonist that is used for wakefulness and to fight excessive daytime sleepiness (EDS). It is the first drug with this indication that is not a controlled substance. It works by increasing the release of histamine, which promotes wakefulness in the brain. Blockade of centrally localized H3 receptors by selective H3 receptor antagonists has been shown to enhance the release of neurotransmitters such as histamine, ACh, dopamine and norepinephrine, among others, which play important roles in cognitive processes. If you are taking adderall, modofinil or another medication to help you stay awake, and would like to come off controlled substances, this is a great peptide and alternative to harsh chemicals. It is a once daily administration in the morning.
- Pitolisant 5mg capsules #30